A cannabis factory with more than 700 plants was discovered when police raided a warehouse on Colwall Street after receiving a tip off.
Officers had sufficient evidence drugs were being grown and distributed from the site.
Two men aged 25 and 27 have been arrested and are to appear in court in due course.
Local Sheffield South East Neighbourhood Policing Team Insp Katie Roland-Wilson said: “Some people may think cannabis is a ‘harmless’ drug however the production and supply of cannabis is often linked to organised crime and the exploitation of vulnerable people who are recruited to look after the grows”.
Insp Katie Roland-Wilson has encouraged the public to keep an eye out for anything that doesn’t look right.
She said: “If you have concerns about a property near you, please report it to us. When we receive intelligence, we will act on it. Together, we can make our streets and communities safer.”